Standard and Method Independent Units for Heparin Anticoagulant Activities
نویسندگان
چکیده
منابع مشابه
Novel method for measurement of heparin anticoagulant activity using SPR.
A novel method has been developed for the easy measurement of heparin's anticoagulant activity using surface plasmon resonance. The anticoagulant activity of target heparin was evaluated by measuring the competitive antithrombin III binding of analyte heparin in the solution phase and USP heparin immobilized on chip surface. Heparins, obtained from different animal sources, and low molecular we...
متن کاملAnticoagulant Therapy Part 1: Heparin
The Thrombotic Process and Its Complications Thrombi are composed of fibrin and blood cells and may form in any part of the cardiovascular system, including the veins, arteries, heart, and microcirculation. Because the relative proportions of cells and fibrin depend on hemodynamic factors, they differ in arterial and venous thrombi.12 Arterial thrombi form under conditions of high flow and are ...
متن کاملRGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activities
Cell adhesion to extracellular matrix components such as fibronectin has a complex basis, involving multiple determinants on the molecule that react with discrete cell surface macromolecules. Our previous results have demonstrated that normal and transformed cells adhere and spread on a 33-kD heparin binding fragment that originates from the carboxy-terminal end of particular isoforms (A-chains...
متن کاملcomparison of enoxaparin sodium and standard heparin for hemodialysis anticoagulation
methods this randomized, crossover study with parallel design was conducted in 45 patients who required maintenance hemodialysis due to end-stage renal failure. four patients with known bleeding disorders, receiving anticoagulant drugs and receiving drugs which could affect heparin activity were excluded. all patients were randomly assigned to receive either enoxaparin sodium (0.7 mg/kg) or sta...
متن کاملHeparin and Related Drugs: Beyond Anticoagulant Activity
Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Thrombosis and Haemostasis
سال: 1993
ISSN: 0340-6245,2567-689X
DOI: 10.1055/s-0038-1649659